The research hypothesis of CONNECT is that combination of macro- and micro-structural tissue parameters (as extracted from diffusion MRI) can be used for comprehensive and quantitative analysis of brain morphology and connectivity
|To investigate, develop and validate the measurement of brain microstructure and connectivity with diffusion MRI.|
|To produce the most comprehensive and accurate assessment of brain macro-structure and micro-structure in vivo to date.|
|To develop an acquisition and analysis framework that will enable the extraction of a multitude of micro-structural parameters.|
|To use micro-structural parameters to constrain probabilistic tractography and provide a reliable and accurate assessment of brain connectivity.|
|To determine the optimal way of measuring tissue microstructure in vivo using diffusion MRI.|
|To characterize the reliability of in-vivo microstructural measurements.|
|To exploit microstructure parameters to improve measures of connectivity.|
|To map basic microstructure parameters over the normal human brain in-vivo.|
|To construct probabilistic atlases of connectivity and microstructure in the normal brain|
WP1 – Comparative study of existing advanced diffusion MRI acquisition and analysis frameworks
Group managers: Chris Clark and Thomas Knoesche
The aim of this WP is to define on the same samples the current status of the different tractography and microstructure procedure available in tissues preparations, animals and human subjects. more ...
WP2 – Development of comprehensive diffusion MRI acquisition and analysis frameworks
Group managers: Geoff Parker
In this WP we will develop and implement an analysis framework for comprehensive assessment both of tractography and microstructural parameters. more ...
WP3 – Optimization of acquisition and analysis routines
Group managers: Tim Behrens
This step of the study will optimize the acquisition and analysis routines. This step is critical in order to provide a robust, clinically acceptable acquisition protocol. In addition we will identify which of the parameters studied in WP1 and WP2 are the most crucial – which will help define the minimal acquisition scheme that should be used. more ...
WP4 – Validation of extracted microstructural and connectivity parameters
Group managers: Tim Dyrby
This step of the research will validate the results of the comprehensive framework. This will be done by comparison with histology and cross validation with several analysis routines. more ...
WP5 – Implementation of the new framework for clinical use
Group managers: Yaniv Assaf
In this WP we will adapt the paradigm we develop to be applicable for clinical use. The main contribution of this WP is a clinically acceptable protocol that will be in line with the aforementioned methodologies and analysis routines. more ....
WP6 – Application of the new methodology for assessment of normal brain connectivity, brain development, neurodegeneration and neurosurgical planning
Group managers: Petra Huppi and Alberto Bizzi
In this WP we will use the methodology developed in WP1-5 to study different aspect of brain anatomy. more ...
|Deliverable no.||Deliverable name||Delivery date|
|1.1||Summary of comparative study||6|
|2.1||Description of comprehensive analysis||14|
|2.2||Development of new acquisition schemes||14|
|3.1||An optimized comprehensive diffusion MRI protocol||20|
|4.1||Summary of validation analysis||24|
|5.1||Clinical setup optimization||34|
|5.2||Connectivity and microstructure software||34|
|6.2||Application in disease||34|
|8.2||Final plan for the use and dissemination of Foreground||34|
|8.3||Report on awareness and wider societal implications||34|